02352i0n a2200337   4500001000600000003000600006005001700012008004300029020001800072040005000090082001100140100003200151245013300183264001100316300003200327336002600359337002800385338002700413520085000440650003001290650005201320650003401372650005501406700003201461700004101493942001401534999001501548952014401563952014401707952016301851u7478SIRSI20251211094535.0|a250904s2023    enka    r     001|0 eng d  a9780323916172  aMiAaPQbengerdaepncMiAaPQdMiAaPQdclrauoh  2612.67  aFang, Evandro Fei,eauthor.10aMolecular, cellular, and metabolic fundamentals of human aging /cEvandro Fei Fang, Linda Hildegard Bergersen, Brian C. Gilmour.  c©2023  a246 pages :billustrations.  atextbtxt2rdacontent  aunmediatedbn2rdamedia  avolumebnc2rdacarrier  aMolecular, Cellular, and Metabolic Fundamentals of Human Aging provides researchers with an overview of the main aging mechanisms and physiology and how they can lead to age-related diseases and conditions. Topics covered include DNA damage and how ineffective repair can lead to cell and tissue aging and decreased functionality, loss of proteostasis, changes to feeding and fasting pathways, mitochondrial dysfunction, the impact of decreased ability of autophagosomes and autophagosomes, cellular senescence, changes to communication molecules, and the impact of stem cell exhaustion. The book also considers the impact of aging within the immune system, the relationship between aging and diseases such as cancers and neurodegenerative conditions, and provides an overview on the dialogue surrounding the topic of aging beyond basic biology.  aAgingxMolecular aspects.  aEnvejecimientoxAspectos moleculares.2localuoh  aAgingxPhysiological aspects.  aEnvejecimientoxAspectos psicológicos.2localuoh  aGilmour, Brian C.,eauthor.  aBergersen, Linda Hildegard,eauthor.  2ddccBOOK  c6494d6494  r2026-03-12 00:00:00i35672005313o612.67 F211m 2023p35672005313t1w2025-10-14yBOOK1040708COL_GRAL00aBCENTRALbBCENTRALd2025-09-04  r2026-03-12 00:00:00i35672005314o612.67 F211m 2023p35672005314t2w2025-10-14yBOOK1040708COL_GRAL00aBCENTRALbBCENTRALd2025-09-04  r2026-03-12 00:00:00i35672010317l0o612.67 F211m 2023p35672010317t3w2025-12-11yBOOK102ddc40708COL_GRAL00aBCENTRALbBCENTRALd2025-10-07g158270.00